TAMILSELVAN JAYAVELU

Education

Degree	Year	University	Major Subject Studied
Ph D	2003-2008	Department of Medical Biochemistry, University of Madras	Biochemistry
M.Sc	2003-2008	Department of Medical Biochemistry, University of Madras	Biochemistry
B.Sc	1997-2000	University of Madras	Biochemistry

Professional experience

Assistant Professor (Centre for Biotechnology, Anna University, Chennai-600025, India) (Period 2010 – till date)
• Research: Understanding the evolution of organ specific metabolism and signaling as well as their status under pathology with special reference to nutrient sensing/homeostasis and organelle turnover.
• Teaching: Cell Biology, Molecular Biology and Genetic Engineering theory and lab courses for undergraduate and post-graduate students.

Postdoctoral Fellow (Period 2009-2010 – Department of Pharmaceutical & Biomedical Sciences, College of Pharmacy, Medical University of South Carolina, Charleston, SC, USA)
• Effect of serotonin receptor agonists on mitochondrial respiration (using XF24/96 extracellular flux analyzer) and biogenesis using primary cultures of renal proximal tubular cells.

Postdoctoral Fellow (Period 2008-2009 – Department of Animal Biology, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, USA)
• Understanding mitochondrial respiratory stress signaling in cancer with a new perspective about the distinctive nature of NFкB (cRel:p50) activation in transgenic mice and c2c12 skeletal myoblast cell culture model.

Doctoral Graduate (Period: 2003-2008 – Department of Medical Biochemistry, University of Madras, Tamilnadu, India)
• Understanding the mechanism(s) underlying mitochondrial respiratory dysfunction and loss of skeletal muscle fibers during aging.

Lectures delivered

• Delivered a Lecture on "Organelle turnover signaling" in Evolutionary Trends in Biochemistry and Molecular Biology Biotrendz 2012 organized by Department of Biochemistry, Bharathidasan University, Trichy, India (20-Sep-2012).

• Delivered a Lecture on "Unaided autophagy is not sufficient to determine mitochondrial quality control in adipose tissue of diet-induced diabetic mice" in 38th Mahabaleshwar seminar on Mitochondria, Metabolism and Energetics organized by Tata Institute for Fundamental Research (TIFR), Mumbai, Mahabaleshwar, India (27-Jan-2014).

• Delivered a Lecture on "Effects of insulin signaling on mitochondrial turnover by targeting autophagy and mitochondrial biogenesis" in 5th International Conference on Molecular Signaling organized by AU-KBC Research Centre, MIT Campus, Anna University (12-Jan-2017).

• Delivered a Lecture on “Biotin deprivation elicits endoplasmic reticulum stress by inhibiting autophagy in aging brain” at Department of Biotechnology, MEPCO Schlenk Engineering College, Sivakasi, India (21-Sep-2019).

• Delivered a lecture on “Biotin deprivation inhibits autophagy to elicit ER stress in the aging brain” at Department of Genetics, University of Madras (24-Feb-2020).

Visits abroad

• Visited Denmark Technical University, Denmark from 11-Jun-2010 to 06-Jul-2010. Purpose of visit: International Research Staff Exchange Programme (IRSES) funded by East West Food-European Union to develop collaboration in the area of metabolic engineering.

• Visited Wageningen University, The Netherlands from 10-Feb-2013 to 31-Mar-2013. Purpose of visit: International Research Staff Exchange Programme (IRSES) funded by East West Food-European Union to develop collaboration in the area of metabolic engineering.

S.No	Project details	Agency	Status
1	Autophagy influences hyperglycemia/ hyperinsulinemia induced adipocyte dysfunction: A possible mechanism of insulin resistance	DBT	Completed
2.	Dysregulation of autophagy influences mitochondria function and biogenesis in adipocytes: A Fundamental approach to insulin resistance.	DST-SERB	Completed
3.	Hyperinsulinemia influences autophagy and mitochondrial biogenesis: A possible mechanism of neuronal ageing	ICMR	Completed
4.	Hyperinsulinemia influences autophagy and endoplasmic reticulum turnover in ageing	UGC	Completed
5.	Differential anaplerotic flux of amino acids influences insulin sensitivity: Role of biotin on biosynthetic capacity of the cell	DST-SERB	Completed
6.	Metabolic Engineering of L. lactis for the production of propionic acid (Role: Co-Investigator)	DBT	Completed

Research Publications

https://orcid.org/0000-0002-7143-352X

Ramaian Santhaseela A, Ganesan D, Rajasekaran S, Selvam S, Jayavelu T* (2020) “Astrocytes resolve endoplasmic reticulum stress through mitochondrial fusion facilitated by biotin availability” Cell stress and Chaperones doi: 10.1007/s12192-020-01129-6

Ramaian Santhaseela A, Ganesan D, Rajasekaran S, Selvam S, Jayavelu T* (2020) “Distinct utilization of micronutrient biotin in and between adipose and brain during aging is associated with lipogenic shift in Wistar rat brain” Nutr Res June 6. doi: 10.1016/j.nutres.2020.06.004.

Ganesan D, Ramaian Santhaseela A, Rajasekaran S, Selvam S, Jayavelu T* (2020). "Astroglial biotin deprivation under endoplasmic reticulum stress uncouples BCAA-mTORC1 role in lipid synthesis to prolong autophagy inhibition in the aging brain”. J Neurochem Feb 7. doi: 10.1111/jnc.14979.

Senthilraja S, Anand RS, Dhasarathan G, Sudarshana R, Tamilselvan J* (2019). Autophagy inhibition by biotin elicits endoplasmic reticulum stress to differentially regulate adipocyte lipid and protein synthesis. Cell stress chaperones 24: 343-350.

Dasagrandhi D, R ASK, Muthuswamy A, Lennox AM, Jayavelu T, Devanathan V, Kesavan Swaminathan J (2018). Ischemia/reperfusion injury in male guinea pigs: An efficient model to investigate myocardial damage in cardiovascular complications. Biomed Pharmacother 99: 469-479.

Periyasamy S, Sathya M, Karthick C, Kandasamy M, Shanmugaapriya S, Tamilselvan J, Jayachandran KS, Anusuyadevi M (2017). Association Studies of Specific Cholesterol Related Genes (APOE, LPL, and CETP) with Lipid Profile and Memory Function: A Correlative Study Among Rural and Tribal Population of Dharmapuri District, J Alzheimers Dis 60, S195-S207

Rasbach KA, Funk JA, Jayavelu T, Green PT, Schnellmann RG (2010). 5-hydroxytryptamine receptor stimulation of mitochondrial biogenesis. J Pharmacol Exp Ther 332 (2), 632-639.

Tamilselvan J, Jayaraman G, Sivarajan K, Panneerselvam C (2007). Age dependent upregulation of p53 and cytochrome c release and susceptibility to apoptosis in skeletal muscle fiber of aged rats: Role of carnitine and lipoic acid. Free Radic Biol Med 43(12), 1656-1669.

Tamilselvan J, Sivarajan K, Anusuyadevi M, Panneerselvam C (2007) Cytochrome c Oxidase Rather than Cytochrome c is a Major Determinant of Mitochondrial Respiratory Capacity in Skeletal Muscle of Aged Rats: Role of Carnitine and Lipoic Acid. Rejuvenation Res 10(3), 311-326.

Savitha S, Tamilselvan J, Anusuyadevi M, Panneerselvam C (2005) Oxidative stress on mitochondrial antioxidant defense system in the aging process: role of DL-α-lipoic acid and L-carnitine. Clin Chim Acta 355: 173-180.

Samuel S, Kathirvel R, Jayavelu T, Chinnakkannu P (2005) Protein oxidative damage in arsenic induced rat brain: influence of DL-α-lipoic acid. Toxicol Lett 155: 27-34.

Contact

Assistant Professor, Centre for Biotechnology

Department of Biotechnology

Anna University, Chennai 600025

tamilselvan@annauniv.edu, tmlsln.j@gmail.com

044 - 2235 8390, 91 9841656368

Dr. Tamilselvan Jayavelu

Assistant Professor,